Ratchathorn Panchaprateep, MD
- Hair Regeneration with Autologous Scalp Cells Suspension
Dr. Ratchathorn Panchaprateep is an associated professor at Division of Dermatology, Chulalongkorn University, Bangkok, Thailand.
She is a board-certified dermatologist and PhD in dermatology from division of dermatology, Chulalongkorn University. Her PhD research is focus on hair follicle stem cells and hair regeneration. Then, she compleed her clinical fellowship in dermatologic surgery at Ramathibodi hospital, Mahidol University and Dermatology, laser and vein specialists of the Carolinas, Charlotte, North Carolina, and United State. She also completed fellowship in hair restoration surgery from DHT clinic (ISHRS) and hair and nail disorders from University of Miami, Miller School of Medicine, Department of Dermatology & Cutaneous Surgery, Miami, Florida, and United State. She also received diplomatic American Board of Hair Restoration Surgery.She has authored many medical papers and has presented a wide range of scientific presentations in the fields of hair restoration surgery, hair biology and disorders as well as laser and cosmetic dermatology.
Hair Regeneration with Autologous Scalp Cells Suspension
Androgenetic alopecia (AGA) is a common hair disorder in both males and females. Traditional approved treatments are topical minoxidil 2-5%, oral finasteride and hair transplantation. However, some patients are not candidate or get unfavorable results with standard treatments. From these reasons, other effective treatments have been developed and hair cell regeneration has attracted attention in this field.
Recently an innovative device, has been developed to allow to obtain viable micro-grafts from mechanical disaggregation of human tissues. This device has been certified by CE as the Class I medical device for the automated mechanical disaggregation. Tissue is mechanically separated into fragments which contain viable progenitor cells responsible for the tissue formation. In addition, this system is able to cut, without crash, the extracellular matrix constituents, which play an important role in healing process.
We conducted a pilot study which aim to determine the efficacy of autologous “scalp micro-grafts” or “scalp cells” for the treatment of androgenetic alopecia. A total of 14 males (Norwood-Hamilton classification of III - IV) were recruited into this study. For each subject, three to four scalp biopsy tissues were taken from occipital area (safe zone) with 4 mm punch. Theses scalp tissues were processed using Rigenera® system. Then cell suspension was injected into thinning area of scalp using 27G needle at amount of 0.1 cc per cm2 at the depth of 3-4 mm. Hair growth was evaluated using (i) hair counts, (ii) standardized global photography, (iii) hair mass and (iv) patient self-assessment questionnaires at first visit, 8, 12 and 24 weeks after injection. The selected thinning area was marked and tattooed for hair count using the FotoFinder® Trichoscale. Global photographs were taken using Nikon D7200 camera (Japan) and evaluated by three blinded dermatologists using standard 7-point rating scale. Hair mass index in the marked area was measured using hair check system® (Divi Inter Co. Miami, Fl, US)
The results of this study will be discussed in the conference.