Pornsayapat Likhitthummagun, M.D.
- Anti-aging effect of oral very high proline complex collagen (DERMOFIX®) on skin properties: a randomized, double-blind, placebo-controlled clinical study
Nowadays, world population are turning to ‘grey population’, so is Thailand. Moreover, the anti-aging health trend is also finding public favor. Taking collagen supplement to rejuvenate the skin is one of a kind. Synthesizing collagen, the body needs specific amino acids – Glycine, Proline, Hydroxyproline, which the researcher called “Proline complex” to make each polypeptide chain before they wound around one another to form triple helix collagen fiber. DERMOFIX®, which is a new very high proline complex containing collagen supplement, will help promoting collagen synthesis naturally and has anti-aging effect on skin properties as well as other collagen containing organs.
The objective of this research is to study the anti-aging effect of the very high proline complex collagen (VHPCC) on skin properties compared to placebo and commercially available collagen (CAV) in Thailand. In this randomized, double blind, placebo-controlled clinical trial, 50 women aged 30-45 years old were randomized to receive the very high proline complex collagen 10 g, commercially available collagen 10 g or placebo once daily for 8 weeks. 6 aging related skin properties, which are skin elasticity, skin hydration, melanin index, transepidermal water loss, skin smoothness and wrinkle were objectively measured at 0, 1, 2, 4, 8 weeks. Photo shooting was done by professional photographer before and after the study. In addition, the blood test was evaluated for the safety of these supplementation as well as for the anti-aging effect by testing Sirt1 gene expression. The satisfaction assessment for skin, knee joint and other collagen containing organs improvement were also assessed.
Results: The very high proline complex collagen showed statistically significant improvement and gain faster effects than the commercially available collagen and placebo, in skin elasticity, hydration, melanin index, transepidermal water loss, smoothness and wrinkles. Most of these effects showed significant difference since the first week of the study. The skin satisfaction assessment results are go along well with the objective measurement. In VHPCC group, some of knee joint problems were assessed impressively improved. Besides, there were beneficial reports on muscle, ligaments and tendons. Feeling energetic instantly after taking was reported. However, the Sirt1 gene expression did not improve in any other group. No adverse event was noted throughout the study.
Conclusion: The study demonstrated that the very high proline complex collagen (DERMOFIX®) supplement was proved safe and led to more significant improvement and gain faster anti-aging effects on skin properties including skin elasticity, skin hydration, melanin index, transepidermal water loss, skin smoothness and wrinkles compared to commercially available collagen and placebo. There was impressively beneficial report on knee joint problems, muscles, ligaments and tendons along with feeling energetic. It will be the best choice for quickly rejuvenating the skin from inside out and anti-aging sustainably.
•American Board of anti-aging and regenerative medicine2017The American Board of Anti-aging and Regenerative Medicine, ABRAAM, USA (candidate)
•M.Sc. program in anti-aging and regenerative medicine2015-2017College of integrated medicine, DPU
•Laser and skin therapy2013Harvard medical school, Harvard university, Boston, USA
•Diploma of dermatology2011-2012Cardiff university, UK
•Fellowship of hair clinic2010-2011Departmentof dermatology, faculty of medicine, Chulalongkornuniversity
•Doctor of medicine (1stclasshonor) Faculty of medicine, chulalongkornuniversity 2003-2009
•Marketing certificate program2014CONC Thammasat university
•TA, Clinical Pathology2010-2011Faculty of medicine, Chulalongkornuniversity
•Pewdee clinic 2011-presentPart time doctor at Central Chidlom, Central Ladphrao
•Doctor life clinic 2011-2017Part time doctor at Future Park Rangsit
•Skin care/supplement product development consultant