Dr. Phawit Norchai, M.D
- The effect of oral Nystatin drug to urine indicant level in dysbiosis
Microorganisms in the intestinal tract are living normally together as a microbiota, an ecological community of commensal, symbiotic and pathogenic microorganism. There are more than 99 % of bacteria, and also Candida albicans, the most common type of fungus in the gut. When benefit bacteria are decreased in quality and quantity, they will definitely affect the intestinal ecosystem. There many factors that stimulate the growth of Candida albicans known as yeast overgrowth that may be one of the intestinal dysbiosis causes.
The effect of oral Nystatin to urinary indicant level has been influenced in this study. The urinary indicant is a urinary marker for dysbiosis in this study. The 25-50 years old, male and female who suspected dysbiosis without underlying diseases, gastrointestinal diseases, probiotics, antibiotics, steroids and antacids were selected as mentioned from the inclusion criteria. The procedure started from the dysbiosis questionnaire answering then passed through by criteria score for dysbiosis, then they had been the urinary indicant testing. According to the criteria of admission, the 30 patients were selected when the results were measured by certified standardized test kit as levels 2, 3 and 4. Each person took 500,000 iu or 5 ml. of Nystatin twice a day then repeated urinary indicant level measurement after 2 and 4 weeks, respectively. The results showed that the urinary indicant was negative 96.67 percent in both 2ndand 4th week, respectively. Cochran Q test analysis showed a statistically significant difference at p value < 0.001 and by McNemar test analysis showed that negative urinary indicant levels were significantly different from prior experiment (p < 0.001) in both of 2nd and 4th week respectively, but at 4th week result compared to 2nd week result was not significantly different at p value > 1.0. As a result, found something related between Nystatin, the Candida killer and the decreasing of urinary indicant level in Dysbiosis. I have suggested that additional functional testing of intestinal yeast overgrowth that are more specific to Candida albicans, such as Urine D-Arabinitol, urinary marker for Candida albicans or Candida sIgA may be considered.
Candida albicans has been known as a well-tolerated and adaptable properties in a different status of intestinal tract. The rapid growth and resistance of Candida albicans could probably be happened. Additional study in the future must be concerned.
Dr. Phawit Norchai received his M.D. from Chiangmai University and his Master degree of science in Antiaging and regenerative Medicine from Dhurakit Pundit University.
He has got American Board of Antiaging and regenerative Medicine (ABAARM)
Dr.Phawit Norchai has been PhD.candidate in clinical epidemiology at Faculty of Medicine Thammasat University for his future position as the research advisor and lecturer in college of integrative medicine Dhurakit Pundit university.
He had experiences as an executive medical doctor director and consultant for many years.
He has been working as a medical doctor in Aesthetic and Antiaging Medicine at Apex Medical Center .