Assist Prof Amornpun Sereemaspun, MD, PhD
Asst. Prof. Dr. Amornpun Sereemaspun, male, molecular biologist and physician, received M.D. degree from Faculty of Medicine at Siriraj hospital, Mahidol University, Thailand in 2000. He had worked as a staff member in Department of Anatomy, Faculty of Medicine, Chulalongkorn University, Bangkok before he continued studying Ph.D. (Human molecular biology) in Jichi Medical University, Tochigi prefecture, Japan from 2002-2006. Since 2007, he has been working as head of division of histology and cell biology, Department of Anatomy, Faculty of Medicine, Chulalongkorn University. His research of interest is focused on nannotechnology application in medicine, including development of novel molecular biomarker, diagnostic tool, and targeted therapy’s drug carrier. In addition, he is one of the founder of nanobiomedicine research unit in his institution. In recent year he has focused on the influence of nanomaterials to the interaction of biological molecules, nanotoxicology especially in cellular senescence, together with the using of nanoparticles in clinical application.
Current Biomarkers of Cellular Aging: From Morphology to Molecular Evidences
The growing of aged population is concerned as one of the major health and socioeconomic problems worldwide. Understanding the biology of cellular aging is critical to health promotion as well as diseases treatment. Since 2013, the hallmarks of aging has just published, this made a great changes in aging science knowledge. The paradigm shift in the cellular senescence shed light in the diagnostics, therapeutics and prevention of accelerated aging of the cell. Currently, numerous types of biomarker of aging have been developed currently, but the validity and the real implementation for biomedical applications have not yet been clearly elucidated. In this talk, various biomarkers of cellular aging were evaluated in many cell types. Cells were induced to be senescence by reactive oxygen species. Biomarkers of aging; including cell morphology, biochemical, genetic, and epigenetic markers, were evaluated both in vitro and ex vivo. Additionally, results of aging parameters of cellular aging from blood samples of healthy people with various chronological ages of Thai population would be discussed in this talk. Our results suggest the insight for appropriate selection of biomarker of aging in the further biomedical implementation.